46. Cuiyan Cao, Long Yu*, Xiuli Zhang, Xuefang Dong, Jingli Yuan, Xinmiao Liang*, Calibration for quantitative Fc-glycosylation analysis of therapeutic IgG1-type monoclonal antibodies by using glycopeptide standards, Analytica Chimica Acta, 2021, 1154, 338306(1-12). 项 目 编 号 : 21804130, 21934005. 关 键 词 : Two-dimensional purification, Fc-glycopeptide standards, Negative ESI-MSMS, Fc glycosylation, Calibrated quantitation, Monoclonal antibodies .

47. Cao Cuiyan, Yu Long*, Yan Jingyu Fu Dongmei, Yuan Jingli, Liang Xinmiao*. Purification of natural neutral N-glycans by using two-dimensional hydrophilic interaction liquid chromatography x porous graphitized carbon chromatography for glycan-microarray assay. TALANTA, 2021, 221, 121382(1-9). 关键词: Purification, Two-dimensional liquid chromatography, Natural N-Glycan, Negative ion fragmentation, Glycan microarray. 项 目 编 号 : 863 Program, 2012AA020203; 21135005.

48. Gaowa Jin, Junjie Ding, Yongzheng Zhou, Donghai Xia, Zhimou Guo∗, Xinmiao Liang. Synthesis and chromatographic evaluation of pyrazinedicarboxylic anhydride bonded stationary phase. Journal of Chromatography A, 2021, 1638, 461825(1-8).关键词: Hydrophilic interaction liquid chromatography, Stationary phase, Amino/anhydride bonded, Selectivity, TCMs. 项目编号: U1608255 , 22074141, 21934005, 2016YFB0301502 , 2017YFD0400600.

49. Yunwei Shi, Xinyi Chen, Jiaxing Liu, Xingjuan Fan, Ying Jin, Jingxiao Gu, Jiale Liang, Xinmiao Liang*, Caiping Wang*. Isoquercetin Improves Inflammatory Response in Rats Following Ischemic Stroke. FRONTIERS IN NEUROSCIENCE,2021, 15, 555543(1-14). 关 键 词 : isoquercetin, neuroprotection, ischemia, inflammation, apoptosis, stroke. 项目编号: This study was supported by the National Natural Science Foundation of China (81970432), Jiangsu Commission of Health Foundation (H2019053), and Nantong University Students’ Innovation and Entrepreneurship Training Program (2018153).

50. Feng Zhang, Jian Huang, Wei Liu, Chao-Ran Wang, Yan-Fang Liu, Dong-Zhu Tu, Xin-Miao Liang, Ling Yang, Wei-Dong Zhang, Hong-Zhuan Chen, Guang-Bo Ge*. Inhibition of drug-metabolizing enzymes by Qingfei Paidu decoction: Implication of herb-drug interactions in COVID-19 pharmacotherapy. Food and Chemical Toxicology, 2021, 149, 111998(1-10).关键词: Qingfei Paidu decoction (QPD), Cytochrome P450 enzymes (CYPs/P450s), Herb-drug interactions (HDIs), CYP3A substrate-drugs. 项 目 编 号 : 2020YFC0845400, 2017YFC1700200, 2017YFC1702000, the NSF of China (81922070, 81973286), Shanghai Science and Technology Innovation Action Plans (20S21901500; 20S21900900) supported by Shanghai Science and Technology Committee, Program of Shanghai Academic/Technology Research Leader (18XD1403600), the Threeyear Action Plan of Shanghai TCM Development (ZY-(2018–2020)-CCCX-5001), Shuguang Program (18SG40) supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission.

51. Lai Wei, Tao Hou, Jiaqi Li, Xiuli Zhang, Han Zhou, Zhenyu Wang, Junxiang Cheng, Kaijing Xiang, Jixia Wang, Yaopeng Zhao*, Xinmiao Liang*. Structure−Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle. JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64(5), 2634-2647. 关键词: 无. 项目编号: 2018ZX09735-002, DICP I201933,DICP ZZBS201803.

52. Dian Liu, Yang Han, Han Zhou, Hongli Jin, Hongjian Kang, FeiFei Huang, Yanfang Liu∗, Xinmiao Liang. Offline preparative three-dimensional HPLC for systematic and efficient purification of alkaloids from Gelsemium elegans Benth. Journal of Chromatography A, 2021, 1640, 461935(1-9). 关键词: Three-dimensional HPLC, Systematic purification, Alkaloids ,Gelsemium elegans Benth. 项目编号: 2018ZX09735-002, the innovation program of sci- ence and research from DICP, CAS ( DICP I201917 ) and Guangxi Innovation-Driven Development Project (GuiKe AA18242040).

53. Liu Wei, Huang Jian, Zhang Feng, Zhang CongCong, Li RongSheng, Wang YongLi, Wang ChaoRan, Liang XinMiao, Zhang WeiDong,Yang Ling, Liu Ping*, Ge GuangBo*, Comprehensive profiling and characterization of the absorbed components and metabolites in mice serum and tissues following oral administration of Qing-Fei-Pai-Du decoction by UHPLC-Q-Exactive-Orbitrap HRMS. CHINESE JOURNAL OF NATURAL MEDICINES, 2021, 19(4), 305-320. 关 键 词 : Qing-Fei-Pai-Du decoction (QFPDD); Corona virus disease 2019 (COVID-19); Chemical profiling; Absorbed components; High-Resolution Mass Spectrometry (HRMS). 项目编号: 2020YFC0845400, 81922070, 20S21901500, 20S21900900, ZY-(2018-2020)-CCCX5001, 18XD1403600.

54. Xu Fangfang, Hou Tao, Shen Aijin, Jin Hongli, Xiao Yuansheng, Yu Wenyi, Li Xiaonong, Wang Jixia*, Liu Yanfang*, Liang Xinmiao*, Mechanism deconvolution of Qing Fei Pai Du decoction for treatment of Coronavirus Disease 2019 (COVID-19) by label-free integrative pharmacology assays, Journal of Ethnopharmacology, 2021, 280, 114488(1-11). 项 目 编 号 : (2020YFC0845400), National Science and Technology Major Project (2018ZX09735-002), and the innovation program of science and research from DICP, CAS (DICP, CAS201803 and DICP I201933). 关键词: COVID-19, Lung cleansing and detoxifying decoction, Dynamic mass redistribution, Target and pathway, GPCR.

55. Yi Zheng, Jinxiang Zhao, Jiaqi Li, Zhimou Guo, Jiajing Sheng, Xianlong Ye, Gaowa Jin, Chaoran Wang, Wengang Chai, Jingyu Yan*, Dong Liu*, Xinmiao Liang*, SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate, International Journal of Biological Macromolecules, 2021, 项目编号: (21934005, 22074143, 81870359), Dalian Science and Technology Innovation Fund of COVID-19 Emergency Project (2020), Wellcome Trust Biomedical Resource grants (218304/Z/19/Z), the March of Dimes Prematurity Research Center grant (22-FY18-82), and Natural Science Foundation of Jiangsu Province (BK20180048). 关键词: SARS-CoV-2, Spike protein, Heparan sulfate, Coagulation, Anticoagulant therapy.

56. 【活性】Tao Hou, Fangfang Xu, Xingrong Peng, Han Zhou, Xiuli Zhang, Minghua Qiu, Jixia Wang*, Yanfang Liu*, Xinmiao Liang. Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products. Journal of Ethnopharmacology, 2021, 270, 113872(1-11). 关键词: Opioid receptors; Dynamic mass redistribution; Natural products; Antagonist; Selectivity. 项 目编号: 2018ZX09735-002, XLYC1908035. the innovation program of science and research from DICP, CAS (DICP, CAS018).

57. Jiaqi Li, Maorong Jiang, JiaoRui Zhou, Junjie Ding, Zhimou Guo, Ming Li, Fei Ding, Wengang Chai, Jingyu Yan*, Xinmiao Liang*, Characterization of rat and mouse acidic milk oligosaccharides based on hydrophilic interaction chromatography coupled with electrospray tandem mass spectrometry, CARBOHYDRATE POLYMERS, 2021, 259, 117734(1-10). 关键词: Milk oligosaccharides; Rat and mouse; Structural characterization; Electrospray mass spectrometry. 项 目 编 号 : 21934005, 22074143, 31900920, 22-FY18-821, WT 218304/Z/19/Z.

58. Zhidong Li, Dasen Jiang, Yingping Dai, Zhuoshun Dai, Yu Jin, Qing Fu*, Xinmiao Liang, Isolation of three polyoxins by reversed-phase liquid chromatography with pure aqueous mobile phase, JOURNAL OF SEPARATION SCIENCE, 2021, 44(10), 2020–2028.关键词: polar C18, polar compounds, polyoxins, preparative high-performance liquid chromatography, reversed-phase liquid chromatography.项目 编号: 2018ZX09735-002.

59. Zhidong Li, Zhuoshun Dai, Dasen Jiang, Yingping Dai, Yu Jin, Qing Fu*, Xinmiao Liang, Bioactivity-guided separation of antifungal compounds by preparative high-performance liquid chromatography, JOURNAL OF SEPARATION SCIENCE, 2021, 44(12), 2382–2390.. 关 键 词 : activity screening, antifungals, polyoxins, preparative high-performance liquid chromatogra-phy. 项 目 编 号 : 2018ZX09735-002.

60.【活性】 Xu Fangfang, Wang Pan, Zhang Xiuli, Hou Tao, Qu Lala, Wang Chaoran, Wang Jixia*, Liu Yanfang*, Liang Xinmiao*,Identification and target-pathway deconvolution of FFA4 agonists with anti-diabetic activity from Arnebia euchroma (Royle) Johnst, Pharmacological Research, 2020. 关键词: Free fatty acid receptor 4, GPR120, Shikonin, Arnebia euchroma (Royle) Johnst, Type 2 diabetes, Chemical compounds studied in this article: Shikonin (PubChem CID: 479503), Acetylshikonin (PubChem CID: 479501). 项目编号: National Science and Technology Major Project (2018ZX09735-002), Project of National Science Foundation of China (81803706) and the innovation program of science and research from DICP, CAS (ZZBS201803, DICP I201933 and DICP I201917), and the Priority Academic Program Development of the Jiangsu Higher Education Institutes (PAPD).